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Structure paper

TitleBiochemical and Structural Insights into Doublecortin-like Kinase Domain 1.
Journal, issue, pagesStructure, Vol. 24, Page 1550-1561, Year 2016
Publish dateMay 17, 2016 (structure data deposition date)
AuthorsPatel, O. / Dai, W. / Mentzel, M. / Griffin, M.D. / Serindoux, J. / Gay, Y. / Fischer, S. / Sterle, S. / Kropp, A. / Burns, C.J. ...Patel, O. / Dai, W. / Mentzel, M. / Griffin, M.D. / Serindoux, J. / Gay, Y. / Fischer, S. / Sterle, S. / Kropp, A. / Burns, C.J. / Ernst, M. / Buchert, M. / Lucet, I.S.
External linksStructure / PubMed:27545623
MethodsX-ray diffraction
Resolution1.71 - 2.85 Å
Structure data

PDB-5jzj:
Crystal structure of DCLK1-KD in complex with AMPPN
Method: X-RAY DIFFRACTION / Resolution: 1.71 Å

PDB-5jzn:
Crystal structure of DCLK1-KD in complex with NVP-TAE684
Method: X-RAY DIFFRACTION / Resolution: 2.85 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-AN2:
AMP PHOSPHORAMIDATE

ChemComp-HOH:
WATER

ChemComp-GUI:
5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]PHENYL]-N'-(2-PROPAN-2-YLSULFONYLPHENYL)PYRIMIDINE-2,4-DIAMINE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / kinase / doublecortin

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