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Structure paper

TitleCrystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455
Journal, issue, pagesPlos One, Vol. 11, Page e0162491-e0162491, Year 2016
Publish dateApr 26, 2016 (structure data deposition date)
AuthorsWu, D. / Guo, M. / Philips, M.A. / Qu, L. / Jiang, L. / Li, J. / Chen, X. / Chen, Z. / Chen, L. / Chen, Y.
External linksPlos One / PubMed:27618313
MethodsX-ray diffraction
Resolution2.352 Å
Structure data

PDB-5jkg:
The crystal structure of FGFR4 kinase domain in complex with LY2874455
Method: X-RAY DIFFRACTION / Resolution: 2.352 Å

Chemicals

ChemComp-6LF:
2-[4-[E-2-[5-[(1R)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / Kinase / Small-molecule Inhibitor / ATP binding pocket / TRANSFERASE-TRANSFERASE INHIBITOR complex

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