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-Structure paper
Title | Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome. |
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Journal, issue, pages | Nucleic Acids Res., Vol. 44, Page 4978-4987, Year 2016 |
Publish date | Mar 31, 2016 (structure data deposition date) |
Authors | Melnikov, S.V. / Soll, D. / Steitz, T.A. / Polikanov, Y.S. |
External links | Nucleic Acids Res. / PubMed:27079977 |
Methods | X-ray diffraction |
Resolution | 2.6 - 2.8 Å |
Structure data | PDB-5j4b: PDB-5j4c: |
Chemicals | ChemComp-MG: ChemComp-K: ChemComp-CPT: ChemComp-ZN: ChemComp-SF4: ChemComp-HOH: |
Source |
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Keywords | RIBOSOME / cisplatin / anticancer drug / cytotoxicity / inhibition of translation / translocation / mRNA channel / GTPase activating center |