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-Structure paper
Title | Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure. |
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Journal, issue, pages | Eur. J. Med. Chem., Vol. 118, Page 170-177, Year 2016 |
Publish date | Mar 29, 2016 (structure data deposition date) |
Authors | Esvan, Y.J. / Zeinyeh, W. / Boibessot, T. / Nauton, L. / Thery, V. / Knapp, S. / Chaikuad, A. / Loaec, N. / Meijer, L. / Anizon, F. ...Esvan, Y.J. / Zeinyeh, W. / Boibessot, T. / Nauton, L. / Thery, V. / Knapp, S. / Chaikuad, A. / Loaec, N. / Meijer, L. / Anizon, F. / Giraud, F. / Moreau, P. |
External links | Eur. J. Med. Chem. / PubMed:27128181 |
Methods | X-ray diffraction |
Resolution | 2.42 - 2.52 Å |
Structure data | PDB-5j1v: PDB-5j1w: |
Chemicals | ChemComp-6FD: ChemComp-GOL: ChemComp-HOH: ChemComp-6FB: ChemComp-PO4: |
Source |
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Keywords | TRANSFERASE / SERINE/THREONINE-PROTEIN KINASE / TYROSINE-PROTEIN KINASE / NUCLEUS / inhibitor / structural genomics consortium / SGC |