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-Structure paper
Title | Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase. |
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Journal, issue, pages | Nat. Chem. Biol., Vol. 12, Page 838-844, Year 2016 |
Publish date | Mar 18, 2016 (structure data deposition date) |
![]() | Ramos-Espiritu, L. / Kleinboelting, S. / Navarrete, F.A. / Alvau, A. / Visconti, P.E. / Valsecchi, F. / Starkov, A. / Manfredi, G. / Buck, H. / Adura, C. ...Ramos-Espiritu, L. / Kleinboelting, S. / Navarrete, F.A. / Alvau, A. / Visconti, P.E. / Valsecchi, F. / Starkov, A. / Manfredi, G. / Buck, H. / Adura, C. / Zippin, J.H. / van den Heuvel, J. / Glickman, J.F. / Steegborn, C. / Levin, L.R. / Buck, J. |
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Methods | X-ray diffraction |
Resolution | 1.79 - 1.86 Å |
Structure data | ![]() PDB-5iv3: ![]() PDB-5iv4: |
Chemicals | ![]() ChemComp-ACT: ![]() ChemComp-GOL: ![]() ChemComp-LRI: ![]() ChemComp-APC: ![]() ChemComp-CA: ![]() ChemComp-PEG: ![]() ChemComp-EDO: ![]() ChemComp-CL: ![]() ChemComp-HOH: ![]() ChemComp-DMS: |
Source |
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![]() | LYASE / human soluble adenylyl cyclase hsAC complex alpha / beta-methyleneadenosine-5'-triphosphate / allosteric inhibitor LRE1 / human soluble Adenylyl Cyclase complex LRE1 inhibitor |