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Title | Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase. |
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Journal, issue, pages | Acs Chem. Biol., Vol. 11, Page 2734-2743, Year 2016 |
Publish date | Mar 7, 2016 (structure data deposition date) |
Authors | Allen, J.G. / Mujacic, M. / Frohn, M.J. / Pickrell, A.J. / Kodama, P. / Bagal, D. / San Miguel, T. / Sickmier, E.A. / Osgood, S. / Swietlow, A. ...Allen, J.G. / Mujacic, M. / Frohn, M.J. / Pickrell, A.J. / Kodama, P. / Bagal, D. / San Miguel, T. / Sickmier, E.A. / Osgood, S. / Swietlow, A. / Li, V. / Jordan, J.B. / Kim, K.W. / Rousseau, A.C. / Kim, Y.J. / Caille, S. / Achmatowicz, M. / Thiel, O. / Fotsch, C.H. / Reddy, P. / McCarter, J.D. |
External links | Acs Chem. Biol. / PubMed:27434622 |
Methods | X-ray diffraction |
Resolution | 1.6 - 1.9 Å |
Structure data | PDB-5in4: PDB-5in5: |
Chemicals | ChemComp-NAP: ChemComp-GDP: ChemComp-6CK: ChemComp-HOH: ChemComp-GFB: ChemComp-GOL: |
Source |
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Keywords | LYASE/INHIBITOR / GDP-mannose 4 / 6 dehydratase / antibody fucosylation / LYASE-INHIBITOR complex / fucosylation |