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TitleDesign and synthesis of novel 3-sulfonylpyrazol-4-amino pyrimidines as potent anaplastic lymphoma kinase (ALK) inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 26, Page 1910-1918, Year 2016
Publish dateMar 7, 2016 (structure data deposition date)
AuthorsZhang, P. / Dong, J. / Zhong, B. / Zhang, D. / Yuan, H. / Jin, C. / Xu, X. / Li, H. / Zhou, Y. / Liang, Z. ...Zhang, P. / Dong, J. / Zhong, B. / Zhang, D. / Yuan, H. / Jin, C. / Xu, X. / Li, H. / Zhou, Y. / Liang, Z. / Ji, M. / Xu, T. / Song, G. / Zhang, L. / Chen, G. / Meng, X. / Sun, D. / Shih, J. / Zhang, R. / Hou, G. / Wang, C. / Jin, Y. / Yang, Q.
External linksBioorg. Med. Chem. Lett. / PubMed:26979157
MethodsX-ray diffraction
Resolution2.12 Å
Structure data

PDB-5imx:
Anaplastic lymphoma kinase (ALK) catalytic domain complexed with novel inhibitor 3-sulfonylpyrazol-4-amino pyrimidine
Method: X-RAY DIFFRACTION / Resolution: 2.12 Å

Chemicals

ChemComp-CZ4:
5-chloro-N~2~-{5-methyl-4-(1-methylpiperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N~4~-{1-methyl-3-[(propan-2-yl)sulfonyl]-1H-pyrazol-4-yl}pyrimidine-2,4-diamine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / Kinase / inhibitor / TRANSFERASE-TRANSFERASE INHIBITOR complex

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