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TitleMolecular architecture of the inner ring scaffold of the human nuclear pore complex.
Journal, issue, pagesScience, Vol. 352, Issue 6283, Page 363-365, Year 2016
Publish dateApr 15, 2016
AuthorsJan Kosinski / Shyamal Mosalaganti / Alexander von Appen / Roman Teimer / Amanda L DiGuilio / William Wan / Khanh Huy Bui / Wim J H Hagen / John A G Briggs / Joseph S Glavy / Ed Hurt / Martin Beck /
PubMed AbstractNuclear pore complexes (NPCs) are 110-megadalton assemblies that mediate nucleocytoplasmic transport. NPCs are built from multiple copies of ~30 different nucleoporins, and understanding how these ...Nuclear pore complexes (NPCs) are 110-megadalton assemblies that mediate nucleocytoplasmic transport. NPCs are built from multiple copies of ~30 different nucleoporins, and understanding how these nucleoporins assemble into the NPC scaffold imposes a formidable challenge. Recently, it has been shown how the Y complex, a prominent NPC module, forms the outer rings of the nuclear pore. However, the organization of the inner ring has remained unknown until now. We used molecular modeling combined with cross-linking mass spectrometry and cryo-electron tomography to obtain a composite structure of the inner ring. This architectural map explains the vast majority of the electron density of the scaffold. We conclude that despite obvious differences in morphology and composition, the higher-order structure of the inner and outer rings is unexpectedly similar.
External linksScience / PubMed:27081072 / PubMed Central
MethodsEM (subtomogram averaging)
Resolution21.4 - 25.2 Å
Structure data

8085

5ijn

5ijo

EMDB-8085: Sub-unit of the Inner ring of the Nuclear Pore complex
PDB-5ijn: Composite structure of the inner ring of the human nuclear pore complex (32 copies of Nup205)
PDB-5ijo: Alternative composite structure of the inner ring of the human nuclear pore complex (16 copies of Nup188, 16 copies of Nup205)
Method: EM (subtomogram averaging) / Resolution: 21.4 Å

EMDB-8086:
Nuclear pore complex
Method: EM (subtomogram averaging) / Resolution: 25.2 Å

EMDB-8087:
Molecular architecture of the inner ring scaffold of the human nuclear pore complex
Method: EM (subtomogram averaging) / Resolution: 21.4 Å

Source
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / Nuclear pore complex / Nucleocytoplasmic transport

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