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TitleDesign, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl carboxamide scaffold.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 26, Page 2328-2332, Year 2016
Publish dateMar 1, 2016 (structure data deposition date)
AuthorsNishiguchi, G.A. / Burger, M.T. / Han, W. / Lan, J. / Atallah, G. / Tamez, V. / Lindvall, M. / Bellamacina, C. / Garcia, P. / Feucht, P. ...Nishiguchi, G.A. / Burger, M.T. / Han, W. / Lan, J. / Atallah, G. / Tamez, V. / Lindvall, M. / Bellamacina, C. / Garcia, P. / Feucht, P. / Zavorotinskaya, T. / Dai, Y. / Wong, K.
External linksBioorg. Med. Chem. Lett. / PubMed:26995528
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-5iis:
Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl-amide scaffold
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-6CB:
3-amino-N-(2'-amino-6'-methyl[4,4'-bipyridin]-3-yl)-6-(2-fluorophenyl)pyridine-2-carboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTransferase/Transferase Inhibitor / Pim1 / moloney murine leukemia / PIM447 / kinase inhibitor / Transferase-Transferase Inhibitor complex

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