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TitleA cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes.
Journal, issue, pagesNat. Chem. Biol., Vol. 12, Page 523-530, Year 2016
Publish dateFeb 26, 2016 (structure data deposition date)
AuthorsMulder, M.P. / Witting, K. / Berlin, I. / Pruneda, J.N. / Wu, K.P. / Chang, J.G. / Merkx, R. / Bialas, J. / Groettrup, M. / Vertegaal, A.C. ...Mulder, M.P. / Witting, K. / Berlin, I. / Pruneda, J.N. / Wu, K.P. / Chang, J.G. / Merkx, R. / Bialas, J. / Groettrup, M. / Vertegaal, A.C. / Schulman, B.A. / Komander, D. / Neefjes, J. / El Oualid, F. / Ovaa, H.
External linksNat. Chem. Biol. / PubMed:27182664
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-5ifr:
Structure of the stable UBE2D3-UbDha conjugate
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Ubiquitin conjugate / dehydroalanine

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