Title Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs. Journal, issue, pages ACS Chem. Biol. , Vol. 11, Page 3400-3411, Year 2016Publish date Feb 21, 2016 (structure data deposition date) AuthorsHeinzlmeir, S. / Kudlinzki, D. / Sreeramulu, S. / Klaeger, S. / Gande, S.L. / Linhard, V. / Wilhelm, M. / Qiao, H. / Helm, D. / Ruprecht, B. ...Heinzlmeir, S. / Kudlinzki, D. / Sreeramulu, S. / Klaeger, S. / Gande, S.L. / Linhard, V. / Wilhelm, M. / Qiao, H. / Helm, D. / Ruprecht, B. / Saxena, K. / Medard, G. / Schwalbe, H. / Kuster, B. External links ACS Chem. Biol. / PubMed:27768280Methods X-ray diffraction Resolution 1.228 - 2.036 Å Structure data PDB-5i9u : Structure viewer Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase Method : X-RAY DIFFRACTION / Resolution : 1.889 Å
PDB-5i9v : Structure viewer Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with AGS Method : X-RAY DIFFRACTION / Resolution : 1.458 Å
PDB-5i9w : Structure viewer Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with ANP Method : X-RAY DIFFRACTION / Resolution : 1.359 Å
PDB-5i9x : Structure viewer Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with bosutinib (SKI-606) Method : X-RAY DIFFRACTION / Resolution : 1.427 Å
PDB-5i9y : Structure viewer Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with dasatinib Method : X-RAY DIFFRACTION / Resolution : 1.228 Å
PDB-5i9z : Structure viewer Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with danusertib (PHA739358) Method : X-RAY DIFFRACTION / Resolution : 1.698 Å
PDB-5ia0 : Structure viewer Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with alisertib (MLN8237) Method : X-RAY DIFFRACTION / Resolution : 1.948 Å
PDB-5ia1 : Structure viewer Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with MLN8054 Method : X-RAY DIFFRACTION / Resolution : 2.036 Å
PDB-5ia2 : Structure viewer Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with compound 66 Method : X-RAY DIFFRACTION / Resolution : 1.619 Å
PDB-5ia3 : Structure viewer Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with PD173955 Method : X-RAY DIFFRACTION / Resolution : 1.788 Å
PDB-5ia4 : Structure viewer Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with foretinib (XL880) Method : X-RAY DIFFRACTION / Resolution : 1.797 Å
PDB-5ia5 : Structure viewer Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with golvatinib (E7050) Method : X-RAY DIFFRACTION / Resolution : 1.776 Å
Chemicals ChemComp-EDO : Structure viewer 1,2-ETHANEDIOL / Ethylene glycol
ChemComp-AGS : Structure viewer PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER / ATP-gamma-S, energy-carrying molecule analogue*YM
ChemComp-ANP : Structure viewer PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP, energy-carrying molecule analogue*YM
ChemComp-DB8 : Structure viewer 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile / inhibitor, medication*YM / Bosutinib
ChemComp-1N1 : Structure viewer N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE / medication*YM / Dasatinib
ChemComp-627 : Structure viewer N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE
ChemComp-A5B : Structure viewer alisertib / inhibitor*YM / Alisertib
ChemComp-ZZL : Structure viewer 4-{[9-CHLORO-7-(2,6-DIFLUOROPHENYL)-5H-PYRIMIDO[5,4-D][2]BENZAZEPIN-2-YL]AMINO}BENZOIC ACID
ChemComp-L66 : Structure viewer 7-(5-hydroxy-2-methylphenyl)-8-(2-methoxyphenyl)-1-methyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione
ChemComp-P17 : Structure viewer 6-(2,6-DICHLORO-PHENYL)-8-METHYL-2-(3-METHYLSULFANYL-PHENYLAMINO)-8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE
ChemComp-88Z : Structure viewer N-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide / Foretinib
Source homo sapiens (human) Keywords TRANSFERASE / TYROSINE-PROTEIN KINASE / RECEPTOR / ATP-BINDING