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Title | Discovery and Pharmacokinetic and Pharmacological Properties of the Potent and Selective MET Kinase Inhibitor 1-{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl]benzothiazol-2-yl}-3-(2-morpholin-4-ylethyl)urea (SAR125844). |
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Journal, issue, pages | J. Med. Chem., Vol. 59, Page 7066-7074, Year 2016 |
Publish date | Jan 15, 2016 (structure data deposition date) |
Authors | Ugolini, A. / Kenigsberg, M. / Rak, A. / Vallee, F. / Houtmann, J. / Lowinski, M. / Capdevila, C. / Khider, J. / Albert, E. / Martinet, N. ...Ugolini, A. / Kenigsberg, M. / Rak, A. / Vallee, F. / Houtmann, J. / Lowinski, M. / Capdevila, C. / Khider, J. / Albert, E. / Martinet, N. / Nemecek, C. / Grapinet, S. / Bacque, E. / Roesner, M. / Delaisi, C. / Calvet, L. / Bonche, F. / Semiond, D. / Egile, C. / Goulaouic, H. / Schio, L. |
External links | J. Med. Chem. / PubMed:27355974 |
Methods | X-ray diffraction |
Resolution | 1.71 - 2.2 Å |
Structure data | PDB-5hlw: PDB-5hni: PDB-5ho6: PDB-5hoa: PDB-5hor: |
Chemicals | ChemComp-CL: ChemComp-62E: ChemComp-HOH: ChemComp-63B: ChemComp-63K: |
Source |
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Keywords | TRANSFERASE / TRANSFERASE INHIBITOR / inhibitor |