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Structure paper

Titlebeta-Subunit Binding Is Sufficient for Ligands to Open the Integrin alpha IIb beta 3 Headpiece.
Journal, issue, pagesJ. Biol. Chem., Vol. 291, Page 4537-4546, Year 2016
Publish dateApr 7, 2015 (structure data deposition date)
AuthorsLin, F.Y. / Zhu, J. / Eng, E.T. / Hudson, N.E. / Springer, T.A.
External linksJ. Biol. Chem. / PubMed:26631735
MethodsX-ray diffraction
Resolution2.599 - 2.85 Å
Structure data

PDB-4z7n:
Integrin alphaIIbbeta3 in complex with AGDV peptide
Method: X-RAY DIFFRACTION / Resolution: 2.599 Å

PDB-4z7o:
Integrin alphaIIbbeta3 in complex with AGDV peptide
Method: X-RAY DIFFRACTION / Resolution: 2.85 Å

PDB-4z7q:
Integrin alphaIIbbeta3 in complex with AGDV-NH2 peptide
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-5hdb:
Integrin alphaIIbbeta3 in complex with Ro-435054
Method: X-RAY DIFFRACTION / Resolution: 2.7012 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-MN:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-MAN:
alpha-D-mannopyranose

ChemComp-MG:
Unknown entry

ChemComp-5YB:
N-(4-carbamimidoylbenzoyl)-beta-alanyl-L-alpha-aspartyl-L-phenylalanine

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsMembrane protein/Immune system / CELL ADHESION / PLATELET AGGREGATION / Membrane protein-Immune system complex / integrin inhibitor / RGD mimetics

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