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TitleDiscovery of a Potent, Selective, Orally Bioavailable, and Efficacious Novel 2-(Pyrazol-4-ylamino)-pyrimidine Inhibitor of the Insulin-like Growth Factor-1 Receptor (IGF-1R).
Journal, issue, pagesJ. Med. Chem., Vol. 59, Page 4859-4866, Year 2016
Publish dateMar 2, 2016 (structure data deposition date)
AuthorsDegorce, S.L. / Boyd, S. / Curwen, J.O. / Ducray, R. / Halsall, C.T. / Jones, C.D. / Lach, F. / Lenz, E.M. / Pass, M. / Pass, S. / Trigwell, C.
External linksJ. Med. Chem. / PubMed:27078757
MethodsX-ray diffraction
Resolution1.9 - 2.4 Å
Structure data

PDB-5fxq:
IGFR-1R complex with a pyrimidine inhibitor.
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-5fxr:
IGFR-1R complex with a pyrimidine inhibitor.
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-5fxs:
IGFR-1R complex with a pyrimidine inhibitor.
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-GD5:
5-chloranyl-4-imidazo[1,2-a]pyridin-3-yl-N-(5-methyl-1-piperidin-4-yl-pyrazol-4-yl)pyrimidin-2-amine

ChemComp-HOH:
WATER

ChemComp-8LN:
5-chloranyl-4-imidazo[1,2-a]pyridin-3-yl-N-(3-methyl-1-piperidin-4-yl-pyrazol-4-yl)pyrimidin-2-amine

ChemComp-ACT:
ACETATE ION

ChemComp-OZN:
2-[4-[4-[[(6Z)-5-chloranyl-6-pyrazolo[1,5-a]pyridin-3-ylidene-1H-pyrimidin-2-yl]amino]-3,5-dimethyl-pyrazol-1-yl]piperidin-1-yl]-N,N-dimethyl-ethanamide

Source
  • homo sapiens (human)
KeywordsTRANSFERASE

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