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TitleDiscovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 26, Page 742-746, Year 2016
Publish dateDec 22, 2015 (structure data deposition date)
AuthorsHan, W. / Menezes, D.L. / Xu, Y. / Knapp, M.S. / Elling, R. / Burger, M.T. / Ni, Z.J. / Smith, A. / Lan, J. / Williams, T.E. ...Han, W. / Menezes, D.L. / Xu, Y. / Knapp, M.S. / Elling, R. / Burger, M.T. / Ni, Z.J. / Smith, A. / Lan, J. / Williams, T.E. / Verhagen, J. / Huh, K. / Merritt, H. / Chan, J. / Kaufman, S. / Voliva, C.F. / Pecchi, S.
External linksBioorg. Med. Chem. Lett. / PubMed:26774655
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-5fi4:
Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-5XV:
~{N}-[6-[5-azanyl-6-[(2~{S})-1,1,1-tris(fluoranyl)propan-2-yl]oxy-pyrazin-2-yl]imidazo[1,2-a]pyridin-2-yl]ethanamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / Lipid kinase inhibitor / TRANSFERASE-TRANSFERASE INHIBITOR complex

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