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TitleCrystal structure of the first bromodomain of human BRD4 in complex with PNZ5 isoxazole inhibitor
Journal, issue, pagesTo Be Published
Publish dateDec 14, 2015 (structure data deposition date)
AuthorsTallant, C. / Clark, P.G.K. / Siejka, P. / Fedorov, O. / Nowak, R. / Srikannathasan, V. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. ...Tallant, C. / Clark, P.G.K. / Siejka, P. / Fedorov, O. / Nowak, R. / Srikannathasan, V. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Muller, S. / Brennan, P.E. / Dixon, D. / Knapp, S.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.85 Å
Structure data

PDB-5fbx:
Crystal structure of the first bromodomain of human BRD4 in complex with PNZ5 isoxazole inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

ChemComp-5W4:
(3~{S})-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methyl-3-phenyl-3~{H}-isoindol-1-one

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / BRG1-associated factor 180 / BAF180 / chromatin remodeling

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