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TitleAttenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA.
Journal, issue, pagesCell Chem Biol, Vol. 23, Page 404-414, Year 2016
Publish dateNov 30, 2015 (structure data deposition date)
AuthorsGood, J.A. / Andersson, C. / Hansen, S. / Wall, J. / Krishnan, K.S. / Begum, A. / Grundstrom, C. / Niemiec, M.S. / Vaitkevicius, K. / Chorell, E. ...Good, J.A. / Andersson, C. / Hansen, S. / Wall, J. / Krishnan, K.S. / Begum, A. / Grundstrom, C. / Niemiec, M.S. / Vaitkevicius, K. / Chorell, E. / Wittung-Stafshede, P. / Sauer, U.H. / Sauer-Eriksson, A.E. / Almqvist, F. / Johansson, J.
External linksCell Chem Biol / PubMed:26991105
MethodsX-ray diffraction
Resolution2.25 Å
Structure data

PDB-5f1r:
The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with a ring-fused 2-pyridone (C10)
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

Chemicals

ChemComp-42O:
(3~{R})-8-cyclopropyl-7-(naphthalen-1-ylmethyl)-5-oxidanylidene-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridine-3-carboxylic acid

ChemComp-HOH:
WATER

Source
  • listeria monocytogenes serovar 1/2a (strain atcc baa-679 / egd-e) (bacteria)
KeywordsDNA BINDING PROTEIN / PrfA / 2-pyridones / Virulence

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