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Structure paper

TitleMechanism of microtubule stabilization by taccalonolide AJ
Journal, issue, pagesNat Commun, Vol. 8, Page 15787-15787, Year 2017
Publish dateNov 27, 2015 (structure data deposition date)
AuthorsWang, Y. / Yu, Y. / Li, G.B. / Li, S.A. / Wu, C. / Gigant, B. / Qin, W. / Chen, H. / Wu, Y. / Chen, Q. / Yang, J.
External linksNat Commun / PubMed:28585532
MethodsX-ray diffraction
Resolution2.05 Å
Structure data

PDB-5ezy:
Crystal structure of T2R-TTL-taccalonolide AJ complex
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

Chemicals

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-CA:
Unknown entry

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-TAJ:
taccalonolide AJ

ChemComp-ACP:
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER / AMP-PCP, energy-carrying molecule analogue*YM

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
  • gallus gallus (chicken)
  • sus scrofa (pig)
  • bos taurus (domestic cattle)
KeywordsSTRUCTURAL PROTEIN / Tubulin / Complex / Inhibitor

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