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Title | Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1 |
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Journal, issue, pages | J. Med. Chem., Vol. 59, Page 282-293, Year 2016 |
Publish date | Nov 3, 2015 (structure data deposition date) |
Authors | Peng, Y.H. / Ueng, S.H. / Tseng, C.T. / Hung, M.S. / Song, J.S. / Wu, J.S. / Liao, F.Y. / Fan, Y.S. / Wu, M.H. / Hsiao, W.C. ...Peng, Y.H. / Ueng, S.H. / Tseng, C.T. / Hung, M.S. / Song, J.S. / Wu, J.S. / Liao, F.Y. / Fan, Y.S. / Wu, M.H. / Hsiao, W.C. / Hsueh, C.C. / Lin, S.Y. / Cheng, C.Y. / Tu, C.H. / Lee, L.C. / Cheng, M.F. / Shia, K.S. / Shih, C. / Wu, S.Y. |
External links | J. Med. Chem. / PubMed:26642377 |
Methods | X-ray diffraction |
Resolution | 2.209 - 2.7 Å |
Structure data | PDB-5ek2: PDB-5ek3: PDB-5ek4: PDB-5etw: |
Chemicals | ChemComp-HEM: ChemComp-5PJ: ChemComp-HOH: ChemComp-5PK: ChemComp-5PF: ChemComp-XNL: |
Source |
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Keywords | OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / inhibitor / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex / IDO1 |