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-Structure paper
Title | Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach |
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Journal, issue, pages | To Be Published |
Publish date | Oct 28, 2015 (structure data deposition date) |
![]() | Innocenti, P. / Woodward, H.L. / Solanki, S. / Naud, N. / Westwood, I.M. / Cronin, N. / Hayes, A. / Roberts, J. / Henley, A.T. / Baker, R. ...Innocenti, P. / Woodward, H.L. / Solanki, S. / Naud, N. / Westwood, I.M. / Cronin, N. / Hayes, A. / Roberts, J. / Henley, A.T. / Baker, R. / Faisal, A. / Mak, G. / Box, G. / Valenti, M. / De Haven Brandon, A. / O'Fee, L. / Saville, J. / Schmitt, J. / Burke, R. / van Montfort, R.L.M. / Raymaud, F.I. / Eccles, S.A. / Linardopoulos, S. / Blagg, J. / Hoelder, S. |
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Methods | X-ray diffraction |
Resolution | 2.18 - 2.66 Å |
Structure data | ![]() PDB-5ehl: ![]() PDB-5eho: |
Chemicals | ![]() ChemComp-0SQ: ![]() ChemComp-HOH: ![]() ChemComp-5O1: ![]() ChemComp-DMS: |
Source |
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![]() | TRANSFERASE / Spindle Assembly Checkpoint (SAC) / Oncology target Pyrido[3 / 4-d]pyrimidine based inhibitors Selective against MPS1 |