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-Structure paper
| Title | Development of a novel tricyclic class of potent and selective FIXa inhibitors. |
|---|---|
| Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 25, Page 5437-5443, Year 2015 |
| Publish date | Oct 27, 2015 (structure data deposition date) |
 Authors | Meng, D. / Andre, P. / Bateman, T.J. / Berger, R. / Chen, Y.H. / Desai, K. / Dewnani, S. / Ellsworth, K. / Feng, D. / Geissler, W.M. ...Meng, D. / Andre, P. / Bateman, T.J. / Berger, R. / Chen, Y.H. / Desai, K. / Dewnani, S. / Ellsworth, K. / Feng, D. / Geissler, W.M. / Guo, L. / Hruza, A. / Jian, T. / Li, H. / Metzger, J. / Parker, D.L. / Reichert, P. / Sherer, E.C. / Smith, C.J. / Sonatore, L.M. / Tschirret-Guth, R. / Wu, J. / Xu, J. / Zhang, T. / Campeau, L.C. / Orr, R. / Poirier, M. / McCabe-Dunn, J. / Araki, K. / Nishimura, T. / Sakurada, I. / Hirabayashi, T. / Wood, H.B. |
 External links | Bioorg. Med. Chem. Lett. / PubMed:26318999 |
| Methods | X-ray diffraction |
| Resolution | 1.841 Å |
| Structure data |  PDB-5egm: |
| Chemicals |  ChemComp-NA:  ChemComp-NHE:  ChemComp-5NY:  ChemComp-HOH: |
| Source |
|
 Keywords | HYDROLASE/HYDROLASE INHIBITOR / SERINE PROTEINASE / BLOOD COAGULATION / COAGULATION FACTOR / HYDROLASE-2 HYDROLASE INHIBITOR COMPLEX / HYDROLASE-HYDROLASE INHIBITOR complex |
homo sapiens (human)