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-Structure paper
Title | Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 25, Page 5743-5747, Year 2015 |
Publish date | Oct 19, 2015 (structure data deposition date) |
Authors | Johannes, J.W. / Almeida, L. / Daly, K. / Ferguson, A.D. / Grosskurth, S.E. / Guan, H. / Howard, T. / Ioannidis, S. / Kazmirski, S. / Lamb, M.L. ...Johannes, J.W. / Almeida, L. / Daly, K. / Ferguson, A.D. / Grosskurth, S.E. / Guan, H. / Howard, T. / Ioannidis, S. / Kazmirski, S. / Lamb, M.L. / Larsen, N.A. / Lyne, P.D. / Mikule, K. / Ogoe, C. / Peng, B. / Petteruti, P. / Read, J.A. / Su, N. / Sylvester, M. / Throner, S. / Wang, W. / Wang, X. / Wu, J. / Ye, Q. / Yu, Y. / Zheng, X. / Scott, D.A. |
External links | Bioorg. Med. Chem. Lett. / PubMed:26546219 |
Methods | X-ray diffraction |
Resolution | 2.2 - 2.24 Å |
Structure data | PDB-5ebt: PDB-5ece: |
Chemicals | ChemComp-BU3: ChemComp-5N8: ChemComp-ZN: ChemComp-HOH: ChemComp-EDO: ChemComp-5N2: ChemComp-ACT: |
Source |
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Keywords | Transferase/Transferase Inhibitor / Tankyrase / PARP / Centrosome clustering / oncology / Transferase-Transferase Inhibitor complex / Inhibitor |