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-Structure paper
Title | GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease. |
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Journal, issue, pages | Br. J. Haematol., Vol. 175, Page 141-153, Year 2016 |
Publish date | Oct 13, 2015 (structure data deposition date) |
Authors | Oksenberg, D. / Dufu, K. / Patel, M.P. / Chuang, C. / Li, Z. / Xu, Q. / Silva-Garcia, A. / Zhou, C. / Hutchaleelaha, A. / Patskovska, L. ...Oksenberg, D. / Dufu, K. / Patel, M.P. / Chuang, C. / Li, Z. / Xu, Q. / Silva-Garcia, A. / Zhou, C. / Hutchaleelaha, A. / Patskovska, L. / Patskovsky, Y. / Almo, S.C. / Sinha, U. / Metcalf, B.W. / Archer, D.R. |
External links | Br. J. Haematol. / PubMed:27378309 |
Methods | X-ray diffraction |
Resolution | 1.8 Å |
Structure data | PDB-5e83: |
Chemicals | ChemComp-HEM: ChemComp-CMO: ChemComp-5L7: ChemComp-GOL:
ChemComp-UNL: ChemComp-HOH: |
Source |
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Keywords | OXYGEN TRANSPORT / MUTANT HUMAN HEMOGLOBIN S[BETAE6V] / R2 QUATERNARY STATE |