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TitleIdentification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies.
Journal, issue, pagesJ. Med. Chem., Vol. 58, Page 8373-8386, Year 2015
Publish dateSep 22, 2015 (structure data deposition date)
AuthorsBurger, M.T. / Nishiguchi, G. / Han, W. / Lan, J. / Simmons, R. / Atallah, G. / Ding, Y. / Tamez, V. / Zhang, Y. / Mathur, M. ...Burger, M.T. / Nishiguchi, G. / Han, W. / Lan, J. / Simmons, R. / Atallah, G. / Ding, Y. / Tamez, V. / Zhang, Y. / Mathur, M. / Muller, K. / Bellamacina, C. / Lindvall, M.K. / Zang, R. / Huh, K. / Feucht, P. / Zavorotinskaya, T. / Dai, Y. / Basham, S. / Chan, J. / Ginn, E. / Aycinena, A. / Holash, J. / Castillo, J. / Langowski, J.L. / Wang, Y. / Chen, M.Y. / Lambert, A. / Fritsch, C. / Kauffmann, A. / Pfister, E. / Vanasse, K.G. / Garcia, P.D.
External linksJ. Med. Chem. / PubMed:26505898
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-5dwr:
Identification of N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1,2 and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-5H7:
N-{4-[(1R,3S,5S)-3-amino-5-methylcyclohexyl]pyridin-3-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTransferase/Transferase Inhibitor / Pim1 / moloney murine leukemia / PIM447 / kinase inhibitor / Transferase-Transferase Inhibitor complex

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