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Structure paper

TitleAllosteric cross-talk in chromatin can mediate drug-drug synergy
Journal, issue, pagesNat Commun, Vol. 8, Page 14860-14860, Year 2017
Publish dateSep 10, 2015 (structure data deposition date)
AuthorsAdhireksan, Z. / Palermo, G. / Riedel, T. / Ma, Z. / Muhammad, R. / Rothlisberger, U. / Dyson, P.J. / Davey, C.A.
External linksNat Commun / PubMed:28358030
MethodsX-ray diffraction
Resolution2.8 - 2.81 Å
Structure data

PDB-5dnm:
Nucleosome core particle containing adducts of ruthenium(II)-toluene PTA complex
Method: X-RAY DIFFRACTION / Resolution: 2.81 Å

PDB-5dnn:
Nucleosome core particle containing adducts of gold(I)-triethylphosphane and ruthenium(II)-toluene PTA complexes
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-MG:
Unknown entry

ChemComp-RAX:
dichloro[(1,2,3,4,5,6-eta)-6-methylbenzene]1,3,5-triaza-7lambda~5~-phosphatricyclo[3.3.1.1~3,7~]dec-7-ylruthenium

ChemComp-AUF:
triethylphosphanuidylgold(1+)

Source
  • xenopus laevis (African clawed frog)
  • synthetic construct (others)
KeywordsSTRUCTURAL PROTEIN/DNA / nucleosome / ruthenium antitumour compound / histone binding / STRUCTURAL PROTEIN-DNA complex / gold antitumour compound

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