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TitleIdentification of novel, in vivo active Chk1 inhibitors utilizing structure guided drug design.
Journal, issue, pagesOncotarget, Vol. 6, Page 35797-35812, Year 2015
Publish dateSep 7, 2015 (structure data deposition date)
AuthorsMassey, A.J. / Stokes, S. / Browne, H. / Foloppe, N. / Fiumana, A. / Scrace, S. / Fallowfield, M. / Bedford, S. / Webb, P. / Baker, L. ...Massey, A.J. / Stokes, S. / Browne, H. / Foloppe, N. / Fiumana, A. / Scrace, S. / Fallowfield, M. / Bedford, S. / Webb, P. / Baker, L. / Christie, M. / Drysdale, M.J. / Wood, M.
External linksOncotarget / PubMed:26437226
MethodsX-ray diffraction
Resolution2.15 Å
Structure data

PDB-5dls:
Identification of Novel, in vivo Active Chk1 Inhibitors Utilizing Structure Guided Drug Design
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

Chemicals

ChemComp-5CV:
1-benzyl-N-(5-{5-[3-(dimethylamino)-2,2-dimethylpropoxy]-1H-indol-2-yl}-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazole-4-carboxamide

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Chk1 / V158411 / fragment / kinase

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