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TitleCrystal structure of the bromodomain of human BRM (SMARCA2) in complex with a hydroxyphenyl propenone inhibitor 17
Journal, issue, pagesTo Be Published
Publish dateSep 3, 2015 (structure data deposition date)
AuthorsTallant, C. / Owen, D.R. / Taylor, A. / Fedorov, O. / Savitsky, P. / Siejka, P. / Srikannathasan, V. / Nowak, R. / von Delft, F. / Arrowsmith, C.H. ...Tallant, C. / Owen, D.R. / Taylor, A. / Fedorov, O. / Savitsky, P. / Siejka, P. / Srikannathasan, V. / Nowak, R. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Knapp, S.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.7 Å
Structure data

PDB-5dkh:
Crystal structure of the bromodomain of human BRM (SMARCA2) in complex with a hydroxyphenyl propenone inhibitor 17
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-5C0:
(2E)-3-[(6S,9R)-4-(cyclopropylamino)-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]pyrimidin-10-yl]-1-(2-hydroxyphenyl)prop-2-en-1-one

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / SWI-SNF complex / chromatin remodeling / Brg associated factors (BAF)

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