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Structure paper

TitleCrystal structure of the bromodomain of human BRM (SMARCA2) in complex with PFI-3 chemical probe
Journal, issue, pagesTo Be Published
Publish dateSep 3, 2015 (structure data deposition date)
AuthorsTallant, C. / Owen, D.R. / Gerstenberger, B.S. / Fedorov, O. / Savitsky, P. / Nunez-Alonso, G. / Fonseca, M. / Krojer, T. / Filippakopoulos, P. / von Delft, F. ...Tallant, C. / Owen, D.R. / Gerstenberger, B.S. / Fedorov, O. / Savitsky, P. / Nunez-Alonso, G. / Fonseca, M. / Krojer, T. / Filippakopoulos, P. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Muller, S. / Knapp, S.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.6 Å
Structure data

PDB-5dkc:
Crystal structure of the bromodomain of human BRM (SMARCA2) in complex with PFI-3 chemical probe
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-5BW:
(2E)-1-(2-hydroxyphenyl)-3-[(1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]hept-2-yl]prop-2-en-1-one

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / SWI-SNF complex / chromatin remodeling / Brg associated factors (BAF) / transcription

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