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-Structure paper
| Title | Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety. |
|---|---|
| Journal, issue, pages | Acs Med. Chem. Lett., Vol. 6, Page 1241-1246, Year 2015 |
| Publish date | Aug 26, 2015 (structure data deposition date) |
 Authors | Ndubaku, C.O. / Crawford, J.J. / Drobnick, J. / Aliagas, I. / Campbell, D. / Dong, P. / Dornan, L.M. / Duron, S. / Epler, J. / Gazzard, L. ...Ndubaku, C.O. / Crawford, J.J. / Drobnick, J. / Aliagas, I. / Campbell, D. / Dong, P. / Dornan, L.M. / Duron, S. / Epler, J. / Gazzard, L. / Heise, C.E. / Hoeflich, K.P. / Jakubiak, D. / La, H. / Lee, W. / Lin, B. / Lyssikatos, J.P. / Maksimoska, J. / Marmorstein, R. / Murray, L.J. / O'Brien, T. / Oh, A. / Ramaswamy, S. / Wang, W. / Zhao, X. / Zhong, Y. / Blackwood, E. / Rudolph, J. |
 External links | Acs Med. Chem. Lett. / PubMed:26713112 |
| Methods | X-ray diffraction |
| Resolution | 2.1 - 2.2 Å |
| Structure data |  PDB-5dey:  PDB-5dfp: |
| Chemicals |  ChemComp-59T:  ChemComp-HOH:  ChemComp-59U:  ChemComp-DMS: |
| Source |
|
 Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / transferase-transferase inhibitor complex |
homo sapiens (human)