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TitleNovel antibody-antibiotic conjugate eliminates intracellular S. aureus.
Journal, issue, pagesNature, Vol. 527, Page 323-328, Year 2015
Publish dateAug 12, 2015 (structure data deposition date)
AuthorsLehar, S.M. / Pillow, T. / Xu, M. / Staben, L. / Kajihara, K.K. / Vandlen, R. / DePalatis, L. / Raab, H. / Hazenbos, W.L. / Morisaki, J.H. ...Lehar, S.M. / Pillow, T. / Xu, M. / Staben, L. / Kajihara, K.K. / Vandlen, R. / DePalatis, L. / Raab, H. / Hazenbos, W.L. / Morisaki, J.H. / Kim, J. / Park, S. / Darwish, M. / Lee, B.C. / Hernandez, H. / Loyet, K.M. / Lupardus, P. / Fong, R. / Yan, D. / Chalouni, C. / Luis, E. / Khalfin, Y. / Plise, E. / Cheong, J. / Lyssikatos, J.P. / Strandh, M. / Koefoed, K. / Andersen, P.S. / Flygare, J.A. / Wah Tan, M. / Brown, E.J. / Mariathasan, S.
External linksNature / PubMed:26536114
MethodsX-ray diffraction
Resolution1.72 Å
Structure data

PDB-5d6c:
Structure of 4497 Fab bound to synthetic wall teichoic acid fragment
Method: X-RAY DIFFRACTION / Resolution: 1.72 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-57S:
4-O-[2-acetamido-2-deoxy-beta-D-glucopyranosyl]-5-O-phosphono-D-ribitol

ChemComp-ACT:
ACETATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Staphylococcus aureus wall teichoic acid antibody MRSA

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