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| Title | Synthesis of potent and broad genotypically active NS5B HCV non-nucleoside inhibitors binding to the thumb domain allosteric site 2 of the viral polymerase. |
|---|---|
| Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 26, Page 4536-4541, Year 2016 |
| Publish date | Jul 31, 2015 (structure data deposition date) |
 Authors | Pierra Rouviere, C. / Amador, A. / Badaroux, E. / Convard, T. / Da Costa, D. / Dukhan, D. / Griffe, L. / Griffon, J.F. / LaColla, M. / Leroy, F. ...Pierra Rouviere, C. / Amador, A. / Badaroux, E. / Convard, T. / Da Costa, D. / Dukhan, D. / Griffe, L. / Griffon, J.F. / LaColla, M. / Leroy, F. / Liuzzi, M. / Loi, A.G. / McCarville, J. / Mascia, V. / Milhau, J. / Onidi, L. / Paparin, J.L. / Rahali, R. / Sais, E. / Seifer, M. / Surleraux, D. / Standring, D. / Dousson, C. |
 External links | Bioorg. Med. Chem. Lett. / PubMed:27520942 |
| Methods | X-ray diffraction |
| Resolution | 1.96 Å |
| Structure data |  PDB-5czb: |
| Chemicals |  ChemComp-55W:  ChemComp-GOL:  ChemComp-MES:  ChemComp-PEG:  ChemComp-SO4:  ChemComp-HOH: |
| Source |
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 Keywords | REPLICATION / HCV POLYMERASE / Idenix / inhibitor / PROTEROS BIOSTRUCTURES GMBH |
hepatitis c virus subtype 1b