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Structure paper

TitleCrystal structures of the M1 and M4 muscarinic acetylcholine receptors.
Journal, issue, pagesNature, Vol. 531, Page 335-340, Year 2016
Publish dateJul 29, 2015 (structure data deposition date)
AuthorsThal, D.M. / Sun, B. / Feng, D. / Nawaratne, V. / Leach, K. / Felder, C.C. / Bures, M.G. / Evans, D.A. / Weis, W.I. / Bachhawat, P. ...Thal, D.M. / Sun, B. / Feng, D. / Nawaratne, V. / Leach, K. / Felder, C.C. / Bures, M.G. / Evans, D.A. / Weis, W.I. / Bachhawat, P. / Kobilka, T.S. / Sexton, P.M. / Kobilka, B.K. / Christopoulos, A.
External linksNature / PubMed:26958838
MethodsX-ray diffraction
Resolution2.6 - 2.7 Å
Structure data

PDB-5cxv:
Structure of the human M1 muscarinic acetylcholine receptor bound to antagonist Tiotropium
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-5dsg:
Structure of the M4 muscarinic acetylcholine receptor (M4-mT4L) bound to tiotropium
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-0HK:
(1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane / antagonist*YM

ChemComp-Y01:
CHOLESTEROL HEMISUCCINATE

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-OLA:
OLEIC ACID

ChemComp-EDT:
{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID

ChemComp-P6G:
HEXAETHYLENE GLYCOL / precipitant*YM

ChemComp-OLC:
(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate

ChemComp-PG6:
1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE

Source
  • homo sapiens (human)
  • enterobacteria phage t4 (virus)
KeywordsHYDROLASE / Acetylcholine / Allosteric Regulation / Carrier Proteins / Cholinergic Antagonists / Tiotropium Receptor / Muscarinic M1 / GPCR / Subtype selectivity / MEMBRANE PROTEIN / Membrane / Signaling / Antagonist

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