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TitleDiscovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma.
Journal, issue, pagesAcs Med. Chem. Lett., Vol. 6, Page 961-965, Year 2015
Publish dateJul 23, 2015 (structure data deposition date)
AuthorsWilliams, T.E. / Subramanian, S. / Verhagen, J. / McBride, C.M. / Costales, A. / Sung, L. / Antonios-McCrea, W. / McKenna, M. / Louie, A.K. / Ramurthy, S. ...Williams, T.E. / Subramanian, S. / Verhagen, J. / McBride, C.M. / Costales, A. / Sung, L. / Antonios-McCrea, W. / McKenna, M. / Louie, A.K. / Ramurthy, S. / Levine, B. / Shafer, C.M. / Machajewski, T. / Renhowe, P.A. / Appleton, B.A. / Amiri, P. / Chou, J. / Stuart, D. / Aardalen, K. / Poon, D.
External linksAcs Med. Chem. Lett. / PubMed:26396681
MethodsX-ray diffraction
Resolution3.17 Å
Structure data

PDB-5ct7:
BRAF in Complex with RAF265
Method: X-RAY DIFFRACTION / Resolution: 3.17 Å

Chemicals

ChemComp-55J:
1-methyl-5-({2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl}oxy)-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / kinase

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