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Title | Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist. |
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Journal, issue, pages | J. Med. Chem., Vol. 58, Page 7526-7548, Year 2015 |
Publish date | Jul 17, 2015 (structure data deposition date) |
Authors | Monn, J.A. / Prieto, L. / Taboada, L. / Hao, J. / Reinhard, M.R. / Henry, S.S. / Beadle, C.D. / Walton, L. / Man, T. / Rudyk, H. ...Monn, J.A. / Prieto, L. / Taboada, L. / Hao, J. / Reinhard, M.R. / Henry, S.S. / Beadle, C.D. / Walton, L. / Man, T. / Rudyk, H. / Clark, B. / Tupper, D. / Baker, S.R. / Lamas, C. / Montero, C. / Marcos, A. / Blanco, J. / Bures, M. / Clawson, D.K. / Atwell, S. / Lu, F. / Wang, J. / Russell, M. / Heinz, B.A. / Wang, X. / Carter, J.H. / Getman, B.G. / Catlow, J.T. / Swanson, S. / Johnson, B.G. / Shaw, D.B. / McKinzie, D.L. |
External links | J. Med. Chem. / PubMed:26313429 |
Methods | X-ray diffraction |
Resolution | 2.65 - 3.15 Å |
Structure data | PDB-5cni: PDB-5cnj: PDB-5cnk: PDB-5cnm: |
Chemicals | ChemComp-GLU: ChemComp-CL: ChemComp-NA: ChemComp-NAG: ChemComp-HOH: ChemComp-52Q: ChemComp-IOD: ChemComp-SO4: ChemComp-MG: |
Source |
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Keywords | SIGNALING PROTEIN / receptor / glutamate / metabotropic / glutamate receptor analog / glutamate receptor / ligand |