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Title | 1,4-Oxazine beta-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads. |
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Journal, issue, pages | J. Med. Chem., Vol. 58, Page 8216-8235, Year 2015 |
Publish date | Jul 16, 2015 (structure data deposition date) |
![]() | Rombouts, F.J. / Tresadern, G. / Delgado, O. / Martinez-Lamenca, C. / Van Gool, M. / Garcia-Molina, A. / Alonso de Diego, S.A. / Oehlrich, D. / Prokopcova, H. / Alonso, J.M. ...Rombouts, F.J. / Tresadern, G. / Delgado, O. / Martinez-Lamenca, C. / Van Gool, M. / Garcia-Molina, A. / Alonso de Diego, S.A. / Oehlrich, D. / Prokopcova, H. / Alonso, J.M. / Austin, N. / Borghys, H. / Van Brandt, S. / Surkyn, M. / De Cleyn, M. / Vos, A. / Alexander, R. / Macdonald, G. / Moechars, D. / Gijsen, H. / Trabanco, A.A. |
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Methods | X-ray diffraction |
Resolution | 2.61 Å |
Structure data | ![]() PDB-5clm: |
Chemicals | ![]() ChemComp-52K: ![]() ChemComp-IOD: ![]() ChemComp-CL: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE / BACE1 PROTEASE Inhibitor / orally bioavailable / brain penetrant / PROTEROS BIOSTRUCTURES GMBH |