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Structure paper

TitleStructural basis for inhibition of the Tob-CNOT7 interaction by a fragment screening approach
Journal, issue, pagesProtein Cell, Vol. 6, Page 924-928, Year 2015
Publish dateJul 11, 2015 (structure data deposition date)
AuthorsBai, Y. / Tashiro, S. / Nagatoishi, S. / Suzuki, T. / Yan, D. / Liu, R. / Tsumoto, K. / Bartlam, M. / Yamamoto, T.
External linksProtein Cell / PubMed:26518565
MethodsX-ray diffraction
Resolution2.3 - 2.328 Å
Structure data

PDB-5ci8:
Crystal structure of human Tob in complex with inhibitor fragment 1
Method: X-RAY DIFFRACTION / Resolution: 2.328 Å

PDB-5ci9:
Crystal structure of human Tob in complex with inhibitor fragment 6
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-53Y:
pyrrolo[1,2-a]quinoxalin-4(5H)-one

ChemComp-549:
1-(propan-2-yl)-1H-benzimidazole-5-carboxylic acid

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION/INHIBITOR / Tob/BTG family / inhibitor / complex / TRANSCRIPTION-INHIBITOR complex

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