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-Structure paper
Title | Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile). |
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Journal, issue, pages | J. Med. Chem., Vol. 58, Page 6653-6664, Year 2015 |
Publish date | Jul 9, 2015 (structure data deposition date) |
![]() | Christopher, J.A. / Aves, S.J. / Bennett, K.A. / Dore, A.S. / Errey, J.C. / Jazayeri, A. / Marshall, F.H. / Okrasa, K. / Serrano-Vega, M.J. / Tehan, B.G. ...Christopher, J.A. / Aves, S.J. / Bennett, K.A. / Dore, A.S. / Errey, J.C. / Jazayeri, A. / Marshall, F.H. / Okrasa, K. / Serrano-Vega, M.J. / Tehan, B.G. / Wiggin, G.R. / Congreve, M. |
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Methods | X-ray diffraction |
Resolution | 2.603 - 3.101 Å |
Structure data | ![]() PDB-5cgc: ![]() PDB-5cgd: |
Chemicals | ![]() ChemComp-OLA: ![]() ChemComp-MES: ![]() ChemComp-51D: ![]() ChemComp-HOH: ![]() ChemComp-51E: |
Source |
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![]() | SIGNALING PROTEIN / 7TM / Receptor / GPCR / Membrane-Protein |