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TitlePharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors.
Journal, issue, pagesMol. Pharmacol., Vol. 89, Page 253-262, Year 2016
Publish dateJul 1, 2015 (structure data deposition date)
AuthorsKristensen, A.S. / Hansen, K.B. / Naur, P. / Olsen, L. / Kurtkaya, N.L. / Dravid, S.M. / Kvist, T. / Yi, F. / Phlsgaard, J. / Clausen, R.P. ...Kristensen, A.S. / Hansen, K.B. / Naur, P. / Olsen, L. / Kurtkaya, N.L. / Dravid, S.M. / Kvist, T. / Yi, F. / Phlsgaard, J. / Clausen, R.P. / Gajhede, M. / Kastrup, J.S. / Traynelis, S.F.
External linksMol. Pharmacol. / PubMed:26661043
MethodsX-ray diffraction
Resolution2.501 Å
Structure data

PDB-5cc2:
STRUCTURE OF THE LIGAND-BINDING DOMAIN OF THE IONOTROPIC GLUTAMATE RECEPTOR-LIKE GLUD2 IN COMPLEX WITH 7-CKA
Method: X-RAY DIFFRACTION / Resolution: 2.501 Å

Chemicals

ChemComp-CKA:
7-Chlorokynurenic acid

ChemComp-GOL:
GLYCEROL

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
KeywordsSIGNALING PROTEIN / Ionotropic glutamate receptor / GluD2 / ligand binding domain / NMDA receptor antagonist

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