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Structure paper

TitleStructural insights into mu-opioid receptor activation.
Journal, issue, pagesNature, Vol. 524, Page 315-321, Year 2015
Publish dateJun 15, 2015 (structure data deposition date)
AuthorsHuang, W. / Manglik, A. / Venkatakrishnan, A.J. / Laeremans, T. / Feinberg, E.N. / Sanborn, A.L. / Kato, H.E. / Livingston, K.E. / Thorsen, T.S. / Kling, R.C. ...Huang, W. / Manglik, A. / Venkatakrishnan, A.J. / Laeremans, T. / Feinberg, E.N. / Sanborn, A.L. / Kato, H.E. / Livingston, K.E. / Thorsen, T.S. / Kling, R.C. / Granier, S. / Gmeiner, P. / Husbands, S.M. / Traynor, J.R. / Weis, W.I. / Steyaert, J. / Dror, R.O. / Kobilka, B.K.
External linksNature / PubMed:26245379
MethodsX-ray diffraction
Resolution2.07 Å
Structure data

PDB-5c1m:
Crystal structure of active mu-opioid receptor bound to the agonist BU72
Method: X-RAY DIFFRACTION / Resolution: 2.07 Å

Chemicals

ChemComp-OLC:
(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate

ChemComp-CLR:
CHOLESTEROL

ChemComp-PO4:
PHOSPHATE ION

ChemComp-P6G:
HEXAETHYLENE GLYCOL / precipitant*YM

ChemComp-VF1:
(2R,3S,3aR,5aR,6R,11bR,11cS)-3a-methoxy-3,14-dimethyl-2-phenyl-2,3,3a,6,7,11c-hexahydro-1H-6,11b-(epiminoethano)-3,5a-methanonaphtho[2,1-g]indol-10-ol

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • lama glama (llama)
KeywordsSignaling Protein/antagonist / Ligands / Mice / Agonists / Morphinans / Activation / Receptors / Opioid / mu / Nanobody / Signaling Protein-antagonist complex

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