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Structure paper

TitleThe fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347, a novel selective FGFR inhibitor
Journal, issue, pagesMol. Cancer Ther., Vol. 13, Page 2547-2558, Year 2014
Publish dateJun 9, 2016 (structure data deposition date)
AuthorsNakanishi, Y. / Akiyama, N. / Tsukaguchi, T. / Fujii, T. / Sakata, K. / Sase, H. / Isobe, T. / Morikami, K. / Shindoh, H. / Mio, T. ...Nakanishi, Y. / Akiyama, N. / Tsukaguchi, T. / Fujii, T. / Sakata, K. / Sase, H. / Isobe, T. / Morikami, K. / Shindoh, H. / Mio, T. / Ebiike, H. / Taka, N. / Aoki, Y. / Ishii, N.
External linksMol. Cancer Ther. / PubMed:25169980
MethodsX-ray diffraction
Resolution2.15 Å
Structure data

PDB-5b7v:
Human FGFR1 kinase in complex with CH5183284
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

Chemicals

ChemComp-LWJ:
[5-amino-1-(2-methyl-1H-benzimidazol-6-yl)-1H-pyrazol-4-yl](1H-indol-2-yl)methanone

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / protein kinase / ATP-binding / inhibitor / TRANSFERASE-TRANSFERASE INHIBITOR complex

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