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TitleDiscovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases
Journal, issue, pagesJ. Med. Chem., Vol. 59, Page 1149-1164, Year 2016
Publish dateJan 7, 2016 (structure data deposition date)
AuthorsLi, P. / Zheng, H. / Zhao, J. / Zhang, L. / Yao, W. / Zhu, H. / Beard, J.D. / Ida, K. / Lane, W. / Snell, G. ...Li, P. / Zheng, H. / Zhao, J. / Zhang, L. / Yao, W. / Zhu, H. / Beard, J.D. / Ida, K. / Lane, W. / Snell, G. / Sogabe, S. / Heyser, C.J. / Snyder, G.L. / Hendrick, J.P. / Vanover, K.E. / Davis, R.E. / Wennogle, L.P.
External linksJ. Med. Chem. / PubMed:26789933
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-5b25:
Crystal structure of human PDE1B with inhibitor 3
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-4QJ:
(11R,15S)-4-{[4-(6-fluoropyridin-2-yl)phenyl]methyl}-8-methyl-5-(phenylamino)-1,3,4,8,10-pentaazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-one

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / Hydrolase / Inhibitor / HYDROLASE-HYDROLASE INHIBITOR complex

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