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TitleStructural and Functional Characterisation of a Specific Antidote for Ticagrelor.
Journal, issue, pagesBlood, Vol. 125, Page 3484-, Year 2015
Publish dateMar 7, 2015 (structure data deposition date)
AuthorsBuchanan, A. / Newton, P. / Pehrsson, S. / Inghardt, T. / Antonsson, T. / Svensson, P. / Sjogren, T. / Oster, L. / Janefeldt, A. / Sandinge, A. ...Buchanan, A. / Newton, P. / Pehrsson, S. / Inghardt, T. / Antonsson, T. / Svensson, P. / Sjogren, T. / Oster, L. / Janefeldt, A. / Sandinge, A. / Keyes, F. / Austin, M. / Spooner, J. / Gennemark, P. / Penney, M. / Howells, G. / Vaughan, T. / Nylander, S.
External linksBlood / PubMed:25788700
MethodsX-ray diffraction
Resolution1.7 - 2.16 Å
Structure data

PDB-5alb:
Ticagrelor antidote candidate MEDI2452 in complex with ticagrelor
Method: X-RAY DIFFRACTION / Resolution: 2.16 Å

PDB-5alc:
Ticagrelor antidote candidate Fab 72 in complex with ticagrelor
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-TIQ:
Ticagrelor / medication, inhibitor*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / ANTIBODY FRAGMENT / ANTIDOTE / DRUG

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