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TitleInhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain.
Journal, issue, pagesElife, Vol. 4, Page e10935-e10935, Year 2015
Publish dateAug 17, 2015 (structure data deposition date)
AuthorsBrumshtein, B. / Esswein, S.R. / Salwinski, L. / Phillips, M.L. / Ly, A.T. / Cascio, D. / Sawaya, M.R. / Eisenberg, D.S.
External linksElife / PubMed:26576950
MethodsX-ray diffraction
Resolution1.05 - 1.49 Å
Structure data

PDB-5acl:
Mcg immunoglobulin variable domain with sulfasalazine
Method: X-RAY DIFFRACTION / Resolution: 1.49 Å

PDB-5acm:
Mcg immunoglobulin variable domain with methylene blue
Method: X-RAY DIFFRACTION / Resolution: 1.05 Å

Chemicals


SASBDB entry, No image

SAS: Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-MBT:
3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM / medication*YM

ChemComp-GOL:
GLYCEROL

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / MCG / IMMUNOGLOBULIN VARIABLE DOMAIN / METHYLENE BLUE

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