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TitlePotent, Selective, and Cns-Penetrant Tetrasubstituted Cyclopropane Class Iia Histone Deacetylase (Hdac) Inhibitors.
Journal, issue, pagesAcs Med. Chem. Lett., Vol. 7, Page 34-, Year 2016
Publish dateMay 22, 2015 (structure data deposition date)
AuthorsLuckhurst, C.A. / Breccia, P. / Stott, A.J. / Aziz, O. / Birch, H.L. / Burli, R.W. / Hughes, S.J. / Jarvis, R.E. / Lamers, M. / Leonard, P.M. ...Luckhurst, C.A. / Breccia, P. / Stott, A.J. / Aziz, O. / Birch, H.L. / Burli, R.W. / Hughes, S.J. / Jarvis, R.E. / Lamers, M. / Leonard, P.M. / Matthews, K.L. / Mcallister, G. / Pollack, S. / Saville-Stones, E. / Wishart, G. / Yates, D. / Dominguez, C.
External linksAcs Med. Chem. Lett. / PubMed:26819662
MethodsX-ray diffraction
Resolution2.65 Å
Structure data

PDB-5a2s:
Potent, selective and CNS-penetrant tetrasubstituted cyclopropane class IIa histone deacetylase (HDAC) inhibitors
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

Chemicals

ChemComp-OTF:
(1S,2S,3S)-1-fluoranyl-2-[4-(5-fluoranylpyrimidin-2-yl)phenyl]-N-oxidanyl-3-phenyl-cyclopropane-1-carboxamide

ChemComp-ZN:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / CLASS IIA HDAC INHIBITORS / HYDROXAMIC ACID / CNS EXPOSURE / TETRASUBSTITUTED CYCLOPROPANE / CYCLOPROPANATION / HUNTINGTON'S DISEASE

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