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-Structure paper
Title | Potent, Selective, and Cns-Penetrant Tetrasubstituted Cyclopropane Class Iia Histone Deacetylase (Hdac) Inhibitors. |
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Journal, issue, pages | Acs Med. Chem. Lett., Vol. 7, Page 34-, Year 2016 |
Publish date | May 22, 2015 (structure data deposition date) |
Authors | Luckhurst, C.A. / Breccia, P. / Stott, A.J. / Aziz, O. / Birch, H.L. / Burli, R.W. / Hughes, S.J. / Jarvis, R.E. / Lamers, M. / Leonard, P.M. ...Luckhurst, C.A. / Breccia, P. / Stott, A.J. / Aziz, O. / Birch, H.L. / Burli, R.W. / Hughes, S.J. / Jarvis, R.E. / Lamers, M. / Leonard, P.M. / Matthews, K.L. / Mcallister, G. / Pollack, S. / Saville-Stones, E. / Wishart, G. / Yates, D. / Dominguez, C. |
External links | Acs Med. Chem. Lett. / PubMed:26819662 |
Methods | X-ray diffraction |
Resolution | 2.65 Å |
Structure data | PDB-5a2s: |
Chemicals | ChemComp-OTF: ChemComp-ZN: ChemComp-NA: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / CLASS IIA HDAC INHIBITORS / HYDROXAMIC ACID / CNS EXPOSURE / TETRASUBSTITUTED CYCLOPROPANE / CYCLOPROPANATION / HUNTINGTON'S DISEASE |