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Structure paper

TitleDesign, synthesis and biological evaluation of novel FGFR inhibitors bearing an indazole scaffold.
Journal, issue, pagesOrg. Biomol. Chem., Vol. 13, Page 7643-7654, Year 2015
Publish dateMay 13, 2015 (structure data deposition date)
AuthorsLiu, J. / Peng, X. / Dai, Y. / Zhang, W. / Ren, S. / Ai, J. / Geng, M. / Li, Y.
External linksOrg. Biomol. Chem. / PubMed:26080733
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-4zsa:
Crystal structure of FGFR1 kinase domain in complex with 7n
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-4UT:
4-(4-ethylpiperazin-1-yl)-N-[6-(3-methoxyphenyl)-2H-indazol-3-yl]benzamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / FGFR1 inhibitor / TRANSFERASE-TRANSFERASE INHIBITOR complex

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