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TitleMechanism and inhibition of human UDP-GlcNAc 2-epimerase, the key enzyme in sialic acid biosynthesis.
Journal, issue, pagesSci Rep, Vol. 6, Page 23274-23274, Year 2016
Publish dateApr 27, 2015 (structure data deposition date)
AuthorsChen, S.C. / Huang, C.H. / Lai, S.J. / Yang, C.S. / Hsiao, T.H. / Lin, C.H. / Fu, P.K. / Ko, T.P. / Chen, Y.
External linksSci Rep / PubMed:26980148
MethodsX-ray diffraction
Resolution2.69 Å
Structure data

PDB-4zht:
Crystal structure of UDP-GlcNAc 2-epimerase
Method: X-RAY DIFFRACTION / Resolution: 2.69 Å

Chemicals

ChemComp-UDP:
URIDINE-5'-DIPHOSPHATE / UDP*YM

ChemComp-NCC:
CYTIDINE-5'-MONOPHOSPHATE-5-N-ACETYLNEURAMINIC ACID

ChemComp-BM7:
2-acetamido-2-deoxy-beta-D-mannopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsISOMERASE / Inhibitor / Complex / Epimerase

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