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TitleDiscovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide.
Journal, issue, pagesJ. Med. Chem., Vol. 58, Page 7370-7380, Year 2015
Publish dateApr 23, 2015 (structure data deposition date)
AuthorsLau, J. / Bloch, P. / Schaffer, L. / Pettersson, I. / Spetzler, J. / Kofoed, J. / Madsen, K. / Knudsen, L.B. / McGuire, J. / Steensgaard, D.B. ...Lau, J. / Bloch, P. / Schaffer, L. / Pettersson, I. / Spetzler, J. / Kofoed, J. / Madsen, K. / Knudsen, L.B. / McGuire, J. / Steensgaard, D.B. / Strauss, H.M. / Gram, D.X. / Knudsen, S.M. / Nielsen, F.S. / Thygesen, P. / Reedtz-Runge, S. / Kruse, T.
External linksJ. Med. Chem. / PubMed:26308095
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-4zgm:
Crystal structure of Semaglutide peptide backbone in complex with the GLP-1 receptor extracellular domain
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-32M:
3,6,9,12,15,18-hexaoxahexacosan-1-ol

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / GLP-1 / receptor / complex

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