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TitleSubstrate Promotes Productive Gas Binding in the alpha-Ketoglutarate-Dependent Oxygenase FIH.
Journal, issue, pagesBiochemistry, Vol. 55, Page 277-286, Year 2016
Publish dateMar 27, 2015 (structure data deposition date)
AuthorsTaabazuing, C.Y. / Fermann, J. / Garman, S. / Knapp, M.J.
External linksBiochemistry / PubMed:26727884
MethodsX-ray diffraction
Resolution2.1 - 2.5 Å
Structure data

PDB-4z1v:
Structure of Factor Inhibiting HIF (FIH) in complex with Fe, NO, and NOG
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-4z2w:
Factor Inhibiting HIF in Complex with Fe, and Alpha-Ketoglutarate
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-OGA:
N-OXALYLGLYCINE / inhibitor*YM

ChemComp-NO:
NITRIC OXIDE

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-FE:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-AKG:
2-OXOGLUTARIC ACID

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / Hypoxia Inducible Factor / Factor Inhibiting HIF / Hydroxylase / Oxygen Sensing / Oxygenase

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