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TitleCell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4.
Journal, issue, pagesScience, Vol. 348, Page 1155-1160, Year 2015
Publish dateMar 19, 2015 (structure data deposition date)
AuthorsWong, Y.L. / Anzola, J.V. / Davis, R.L. / Yoon, M. / Motamedi, A. / Kroll, A. / Seo, C.P. / Hsia, J.E. / Kim, S.K. / Mitchell, J.W. ...Wong, Y.L. / Anzola, J.V. / Davis, R.L. / Yoon, M. / Motamedi, A. / Kroll, A. / Seo, C.P. / Hsia, J.E. / Kim, S.K. / Mitchell, J.W. / Mitchell, B.J. / Desai, A. / Gahman, T.C. / Shiau, A.K. / Oegema, K.
External linksScience / PubMed:25931445
MethodsX-ray diffraction
Resolution2.65 Å
Structure data

PDB-4yur:
Crystal Structure of Plk4 Kinase Domain Bound to Centrinone
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

Chemicals

ChemComp-4J7:
2-({2-fluoro-4-[(2-fluoro-3-nitrobenzyl)sulfonyl]phenyl}sulfanyl)-5-methoxy-N-(3-methyl-1H-pyrazol-5-yl)-6-(morpholin-4-yl)pyrimidin-4-amine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTransferase/Transferase Inhibitor / Transferase / Protein Kinase / Inhibitor / Transferase-Transferase Inhibitor complex

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