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-Structure paper
Title | Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases. |
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Journal, issue, pages | J. Med. Chem., Vol. 58, Page 7195-7216, Year 2015 |
Publish date | Mar 17, 2015 (structure data deposition date) |
![]() | Farmer, L.J. / Ledeboer, M.W. / Hoock, T. / Arnost, M.J. / Bethiel, R.S. / Bennani, Y.L. / Black, J.J. / Brummel, C.L. / Chakilam, A. / Dorsch, W.A. ...Farmer, L.J. / Ledeboer, M.W. / Hoock, T. / Arnost, M.J. / Bethiel, R.S. / Bennani, Y.L. / Black, J.J. / Brummel, C.L. / Chakilam, A. / Dorsch, W.A. / Fan, B. / Cochran, J.E. / Halas, S. / Harrington, E.M. / Hogan, J.K. / Howe, D. / Huang, H. / Jacobs, D.H. / Laitinen, L.M. / Liao, S. / Mahajan, S. / Marone, V. / Martinez-Botella, G. / McCarthy, P. / Messersmith, D. / Namchuk, M. / Oh, L. / Penney, M.S. / Pierce, A.C. / Raybuck, S.A. / Rugg, A. / Salituro, F.G. / Saxena, K. / Shannon, D. / Shlyakter, D. / Swenson, L. / Tian, S.K. / Town, C. / Wang, J. / Wang, T. / Wannamaker, M.W. / Winquist, R.J. / Zuccola, H.J. |
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Methods | X-ray diffraction |
Resolution | 1.78 - 2.52 Å |
Structure data | ![]() PDB-4ytc: ![]() PDB-4ytf: ![]() PDB-4yth: ![]() PDB-4yti: |
Chemicals | ![]() ChemComp-4HW: ![]() ChemComp-HOH: ![]() ChemComp-4HZ: ![]() ChemComp-467: ![]() ChemComp-VJK: |
Source |
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![]() | Transferase/Transferase Inhibitor / janus kinase / kinase / inhibitor / autoimmune / Transferase-Transferase Inhibitor complex / jak3 kinase / jak2 kinase / jak2 / jak3 |